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Description:As the plate grows, it significantly separates the cervix and the urogenital sinus; eventually, the central cells of the plate break down to form the vaginal lumen. Pharmacologically , this has the potential advantage of promoting therapeutic effects primarily in the vagina or nearby structures such as the vaginal portion of cervix with limited systemic adverse effects compared to other routes of administration. It forms folds transverse ridges or rugae , which are more prominent in the outer third of the vagina; their function is to provide the vagina with increased surface area for extension and stretching. These are inserted into the vagina and provide continuous, low dose and consistent drug levels in the vagina and throughout the body.